Phenotypes of atopic dermatitis.

This review summarizes the current understanding of phenotypes (clinical manifestations) atopic dermatitis (AD) based on morphological and some laboratory diagnostic tools (total IgE level, sensitization status, filaggrin mutations). The author gives a chronology study AD phenotypes, including use modern statistical methods (clusters). Recent studies have described unique in patients with colonized by Staphylococcus aureus; food allergies; herpes eczema, history infection. At same time, it is quite obvious that are determined molecular mechanisms (endotype), which associated age patients, severity disease, persistence, etc. Recently, publications appeared confirmed features course disease different ethnic groups (European-American Asian phenotypes), immunopathogenetic differences characteristic races people. Together, endo- will help to better identify most optimal approach personalized treatment these patients. Ultimately, such important for developing classification phenotypes.